Rgs5 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of vascular associated smooth muscle cell proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and visual system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and essential hypertension. Orthologous to human RGS5 (regulator of G protein signaling 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs5 |
| Official Name | regulator of G-protein signaling 5 [Source:MGI Symbol;Acc:MGI:1098434] |
| Ensembl ID | ENSMUSG00000026678 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 5 |
| Synonyms | 1110070A02Rik, LOC100505773, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Rgs5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
- uterine serous papillary cancer
- primary pulmonary hypertension
- parathyroid adenoma
- cardiac fibrosis
- uterine leiomyoma
- leiomyomatosis
- cardiac hypertrophy
role in cell
- phosphorylation in
- activation in
- expression in
- apoptosis
- growth
- production in
- chemotaxis
- accumulation in
- binding
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity