Card11 Gene Summary [Mouse]
Predicted to enable CARD domain binding activity. Involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell receptor signaling pathway; and positive regulation of canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Located in immunological synapse. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Card11 |
| Official Name | caspase recruitment domain family, member 11 [Source:MGI Symbol;Acc:MGI:1916978] |
| Ensembl ID | ENSMUSG00000036526 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family, member 11 |
| Synonyms | 0610008L17RIK, 2410011D02Rik, BENTA, BIMP3, CARDS11, CARMA1, caspase recruitment domain family member 11, caspase recruitment domain family, member 11, IMD11, IMD11A, LOC100363332, LOC102723892, PPBL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Card11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- Rabaptin-like protein
- PKC phosphorylation site
- canonical PDZ domain
- inhibitory domain
- Rabaptin
- linker domain
- coiled-coil domain
- protein binding
- TATA element modulatory factor 1 TATA binding
- Src Homology 3 domain superfamily
- kinase
- Caspase recruitment domain
- Trichohyalin-plectin-homology domain
- ubiquitination site
- guanylate kinase-like domain
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Card11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- obesity
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- ovarian carcinoma
- epithelial ovarian cancer
- advanced-stage typical follicular lymphoma
- follicular non-Hodgkin disease
- advanced cancer
phenotypes
- abnormal B cell differentiation
- abnormal B cell physiology
- abnormal B cell proliferation
- abnormal CD4-positive CD25-positive alpha-beta regulatory T cell morphology
- abnormal NK cell physiology
- abnormal T cell activation
- abnormal T cell differentiation
- abnormal T cell proliferation
- abnormal T-helper 2 cell differentiation
- abnormal cytokine secretion
- abnormal cytotoxic T cell physiology
- abnormal double-negative T cell morphology
- abnormal immune system physiology
- abnormal interleukin-2 secretion
- abnormal lymphocyte morphology
- absent B-1a cells
- absent immature B cells
- decreased B cell number
- decreased B cell proliferation
- decreased B-1 B cell number
- decreased B-1a cell number
- decreased IgA level
- decreased IgE level
- decreased IgG level
- decreased IgG1 level
- decreased IgG2a level
- decreased IgG2b level
- decreased IgG2c level
- decreased IgG3 level
- decreased IgM level
- decreased NK T cell number
- decreased NK cell number
- decreased T cell proliferation
- decreased airway responsiveness
- decreased central memory CD4-positive alpha-beta T cell number
- decreased circulating interleukin-4 level
- decreased circulating interleukin-5 level
- decreased effector memory CD4-positive alpha-beta T cell number
- decreased effector memory CD8-positive alpha-beta T cell number
- decreased gamma-delta T cell number
- decreased immunoglobulin level
- decreased interferon-gamma secretion
- decreased interleukin-2 secretion
- decreased mature B cell number
- decreased memory T cell number
- decreased regulatory T cell number
- decreased response to antigen
- dermatitis
- erythroderma
- impaired humoral immune response
- increased B-1 B cell number
- increased B-1a cell number
- increased B-1b cell number
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgE level
- increased NK T cell number
- increased T cell number
- increased alpha-beta T cell number
- increased immunoglobulin level
- increased inflammatory response
- lung inflammation
- lymph node hyperplasia
- spleen hyperplasia
role in cell
- expression in
- phosphorylation in
- growth
- activation in
- cell death
- induction in
- production in
- activation
- differentiation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- immunological synapses
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Card11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell costimulation
- B cell differentiation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of B cell differentiation
- protein homooligomerization
- GDP metabolic process
- B cell proliferation
- GMP metabolic process
- regulation of apoptotic process
- I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- regulation of T cell differentiation
- positive regulation of T cell receptor signaling pathway
- thymic T cell selection
- CD4-positive, alpha-beta T cell proliferation
- homeostasis of number of cells
- positive regulation of B cell proliferation
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- CBM complex
- extracellular vesicular exosome
- cytoplasm
- membrane raft
- cytosol
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanylate kinase activity
- CARD domain binding