Gad2 Gene Summary [Mouse]
Predicted to enable glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Predicted to be involved in gamma-aminobutyrate shunt and gamma-aminobutyric acid biosynthetic process. Located in axon; cytoplasm; and synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Used to study epilepsy and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; diabetes mellitus (multiple); drug psychosis; and heroin dependence. Orthologous to human GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gad2 |
| Official Name | glutamic acid decarboxylase 2 [Source:MGI Symbol;Acc:MGI:95634] |
| Ensembl ID | ENSMUSG00000026787 |
| Bio databases IDs | |
| Aliases | glutamic acid decarboxylase 2 |
| Synonyms | 6330404F12RIK, Gad6, Gad64 alpha, Gad64 beta, Gad64 α, Gad64 β, GAD65, GAD(65), glutamate decarboxylase 2, glutamic acid decarboxylase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gad2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glutamate decarboxylase
- pyridoxal phosphate binding
- binding protein
- AAT_I
- glutamate binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Gad2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hyperammonemia
- arthralgia
- insulin-dependent diabetes mellitus
- neuralgia
- schizophrenia
- bipolar depression
- epilepsy
- seizures
- tinnitus
role in cell
- proliferation
- production in
- survival
- activation
- fusion
- fusion in
- quantity
- plasticity
- transactivation in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- synaptic vesicle membrane
- presynaptic regions
- perinuclear region
- membrane surface
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- neurites
- nerve ending
- synaptosomes
- synapse
- cytoplasmic vesicles
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- presynaptic terminals
- exosomes
- clathrin-coated vesicles
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gad2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to progesterone stimulus
- response to cocaine
- synaptic transmission
- response to xenobiotic stimulus
- cellular response to hypoxia
- glutamate decarboxylation to succinate
- gamma-aminobutyric acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- inhibitory synapse
- perinuclear region of cytoplasm
- clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
- cytoplasm
- cytosol
- Golgi membrane
- synaptic vesicle membrane
- neuronal cell body
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein binding
- glutamate decarboxylase activity
- glutamate binding