Cobll1 Gene Summary [Mouse]
Predicted to enable actin monomer binding activity. Is expressed in several structures, including 1st branchial arch; extraembryonic component; forelimb bud; gut; and nose. Orthologous to human COBLL1 (cordon-bleu WH2 repeat protein like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cobll1 |
| Official Name | Cobl-like 1 [Source:MGI Symbol;Acc:MGI:2442894] |
| Ensembl ID | ENSMUSG00000034903 |
| Bio databases IDs | |
| Aliases | Cobl-like 1 |
| Synonyms | 1810047P18RIK, Cobl-like 1, COBLR1, cordon-bleu WH2 repeat protein-like 1, D430044D16Rik, KIAA0977 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cobll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cordon-bleu ubiquitin-like domain
- WH2
- Raf-like Ras-binding domain
- protein binding
- N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypercholesterolemia
- psoriasis
- insulin resistance
- metabolic syndrome X
- diabetic neuropathy
- non-insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
- gastric carcinoma
- gastric epithelial cancer
- diabetes mellitus
role in cell
- phosphorylation in
- apoptosis
- growth
- morphogenesis
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cobll1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- cadherin binding
- actin monomer binding