Slc4a10 Gene Summary [Mouse]
Enables sodium,bicarbonate:chloride antiporter activity and sodium:bicarbonate symporter activity. Involved in regulation of short-term neuronal synaptic plasticity and visual perception. Acts upstream of or within several processes, including brain development; locomotory exploration behavior; and proton transmembrane transport. Located in several cellular components, including GABA-ergic synapse; basolateral plasma membrane; and dendrite. Is expressed in several structures, including gut; nervous system; sensory organ; and testis. Orthologous to human SLC4A10 (solute carrier family 4 member 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc4a10 |
| Official Name | solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 [Source:MGI Symbol;Acc:MGI:2150150] |
| Ensembl ID | ENSMUSG00000026904 |
| Bio databases IDs | |
| Aliases | solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 |
| Synonyms | mKIAA4136, NBCn2, NCBE, solute carrier family 4 member 10, solute carrier family 4, sodium bicarbonate cotransporter-like, member 10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc4a10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium ion transporter
- protein binding
- anion exchange protein
- metal ion transporter
- chloride transporter
- bicarbonate transporter
- anion transporter
- sodium:bicarbonate symporter
- HCO3- transporter family
- Band 3 cytoplasmic domain
- antiporter
- inorganic anion exchanger
- transporter
Pathways
Biological processes and signaling networks where the Slc4a10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neuroticism
- bipolar disorder
- neurodevelopmental disorder with hypotonia and characteristic brain abnormalities
- mixed connective tissue disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- migraines
- weight gain
- insulin-dependent diabetes mellitus
- seizures
regulates
- bicarbonate
- H+
role in cell
- development
- homeostasis in
- function
- pH
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- somatodendritic region
- apical membrane
- basolateral membrane
- synapse
- perikaryon
- dendrites
- axon terminals
- presynaptic terminals
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc4a10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- transmembrane transport
- locomotory exploration behavior
- post-embryonic development
- brain morphogenesis
- visual perception
- pyramidal neuron development
- response to light stimulus
- chloride transport
- regulation of intracellular pH
- sodium ion transmembrane transport
- regulation of short-term neuronal synaptic plasticity
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- dendrite
- membrane
- synapse
- neuronal cell body
- perikaryon
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- sodium:bicarbonate symporter activity
- inorganic anion exchanger activity