Tia1 Gene Summary [Mouse]
Enables mRNA 3'-UTR AU-rich region binding activity. Involved in negative regulation of translation and regulation of alternative mRNA splicing, via spliceosome. Acts upstream of or within negative regulation of cytokine production. Located in cytoplasmic stress granule and nuclear stress granule. Is expressed in several structures, including alimentary system; brain; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tia1 |
| Official Name | cytotoxic granule-associated RNA binding protein 1 [Source:MGI Symbol;Acc:MGI:107914] |
| Ensembl ID | ENSMUSG00000071337 |
| Bio databases IDs | |
| Aliases | cytotoxic granule-associated RNA binding protein 1 |
| Synonyms | 2310050N03Rik, ALS26, cytotoxic granule-associated RNA binding protein 1, mTIA-1, TIA1 cytotoxic granule-associated RNA binding protein, WDM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tia1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- poly(A) binding protein
- protein binding
- PR domain
- RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
- hepatic fibrosis
- colorectal cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- arthritis
- growth failure
- mature T-cell neoplasia
role in cell
- cell death
- expression in
- apoptosis
- migration
- generation in
- proliferation
- binding in
- formation
- binding
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ribonucleoprotein granule
- Cytoplasm
- granules
- cytoplasmic aggregates
- cytosol
- nucleoplasm
- cytotoxic granule
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tia1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- apoptotic process
- regulation of nuclear mRNA splicing, via spliceosome
- mRNA processing
- negative regulation of cytokine production
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear stress granule
- cytoplasmic stress granule
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA 3'-UTR AU-rich region binding
- poly(A) RNA binding
- mRNA 3'-UTR binding