Trim65 Gene Summary [Mouse]
Enables ubiquitin-protein transferase activity. Involved in protein K63-linked ubiquitination. Acts upstream of or within several processes, including innate immune response; positive regulation of protein oligomerization; and positive regulation of type I interferon production. Located in cytoplasm. Orthologous to human TRIM65 (tripartite motif containing 65). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim65 |
| Official Name | tripartite motif-containing 65 [Source:MGI Symbol;Acc:MGI:2442815] |
| Ensembl ID | ENSMUSG00000054517 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 65 |
| Synonyms | 4732463G12Rik, tripartite motif-containing 65 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim65 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- F-type ATP synthase, membrane subunit b
- coiled-coil domain
- protein domain specific binding
- enzyme
- Ring finger domain
- associated with SPRY domains
- ATP synthase B/B' CF(0)
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- ubiquitin-protein transferase activity
- B-box zinc finger
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- white matter hyperintensities
- coronary artery disease
- hypertension
- hyperlipidemia
role in cell
- expression in
- activation in
- binding in
- migration
- K48 polyubiquitination in
- degradation in
- K63 polyubiquitination in
- ubiquitination in
- autophagy by
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim65 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- positive regulation of interferon-alpha production
- protein K48-linked ubiquitination
- positive regulation of protein oligomerization
- negative regulation of inflammatory response
- positive regulation of interferon-beta production
- positive regulation of protein phosphorylation
- protein K63-linked ubiquitination
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding