Abraxas2 Gene Summary [Mouse]
Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of apoptotic process; protein K63-linked deubiquitination; and response to ischemia. Acts upstream of or within cellular response to freezing. Located in cytoplasm and nucleus. Orthologous to human ABRAXAS2 (abraxas 2, BRISC complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abraxas2 |
| Official Name | BRISC complex subunit [Source:MGI Symbol;Acc:MGI:1926116] |
| Ensembl ID | ENSMUSG00000030965 |
| Bio databases IDs | |
| Aliases | BRISC complex subunit |
| Synonyms | abraxas 2, BRISC complex subunit, ABRO1, BRISC complex subunit, C430003P19Rik, FAM175B, KIAA0157, RGD1308918 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abraxas2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein binding
- Abraxas-like_domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- metastasis
- lung adenocarcinoma formation
regulated by
- lipopolysaccharide
- NLRP3
- D-galactosamine
role in cell
- number
- phosphorylation in
- activation in
- apoptosis
- production in
- binding in
- expansion
- assembly
- degradation
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- midbody
- cytosol
- spindle pole
- minus ends of microtubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abraxas2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- response to ischemia
- attachment of spindle microtubules to kinetochore
- chromosome segregation
- mitotic cell cycle
- protein K63-linked deubiquitination
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- spindle pole centrosome
- nucleus
- centrosome
- BRISC complex
- cytoplasm
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- polyubiquitin binding
- microtubule binding