Nusap1 Gene Summary [Mouse]
Enables microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitotic sister chromatid segregation and positive regulation of mitotic nuclear division. Located in nucleolus. Is active in mitotic spindle. Is expressed in several structures, including genitourinary system; gut; immune system; respiratory system; and skin. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nusap1 |
| Official Name | nucleolar and spindle associated protein 1 [Source:MGI Symbol;Acc:MGI:2675669] |
| Ensembl ID | ENSMUSG00000027306 |
| Bio databases IDs | |
| Aliases | nucleolar and spindle associated protein 1 |
| Synonyms | 2610201A12Rik, ANKT, BM-037, HQ0310 PRO0310P1, LNP, nucleolar and spindle associated protein 1, NUSAP, PRO0310p1, Q0310, SAPL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nusap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein binding
- Nucleolar and spindle-associated protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- non-small cell lung cancer
- prostate cancer
- HER2 negative hormone receptor negative breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- liver cancer
- organismal death
- papillary renal cell carcinoma
role in cell
- formation
- binding in
- formation in
- abnormal morphology
- aberration
- mitosis
- bundling
- condensation
- misalignment in
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- nucleoli
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nusap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic chromosome condensation
- establishment of mitotic spindle localization
- cytokinesis after mitosis
- mitotic sister chromatid segregation
- positive regulation of mitosis
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- cytoplasm
- chromosome
- nucleolus
- microtubule
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- microtubule binding