Peak1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including focal adhesion assembly; regulation of focal adhesion assembly; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and focal adhesion. Orthologous to human PEAK1 (pseudopodium enriched atypical kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Peak1 |
| Official Name | pseudopodium-enriched atypical kinase 1 [Source:MGI Symbol;Acc:MGI:2442366] |
| Ensembl ID | ENSMUSG00000074305 |
| Bio databases IDs | |
| Aliases | pseudopodium-enriched atypical kinase 1 |
| Synonyms | 1110049L02Rik, 9530046P14, AA690169, C230081A13Rik, KIAA2002, mKIAA2002, pseudopodium-enriched atypical kinase 1, RGD1312026, SG269, SGK269 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Peak1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Kinase regulatory loop binding domain
- non-membrane spanning protein tyrosine kinase
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Peak1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- colon cancer
- inflammatory bowel disease
- refractive error
- prostate cancer
- metabolic syndrome X
- malocclusion
- otosclerosis
- prostatic intraepithelial neoplasm
role in cell
- phosphorylation in
- growth
- migration
- binding in
- assembly
- assembly in
- cell spreading
- disassembly in
- regulation in
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- actin cytoskeleton
- actin filaments
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Peak1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of focal adhesion assembly
- substrate adhesion-dependent cell spreading
- protein autophosphorylation
- focal adhesion assembly
- protein phosphorylation
- cell migration
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- protein kinase activity