Napb Gene Summary [Mouse]
Enables syntaxin binding activity. Involved in regulation of synaptic vesicle priming. Acts upstream of or within SNARE complex disassembly and glutamatergic synaptic transmission. Located in myelin sheath. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is active in glutamatergic synapse. Is expressed in central nervous system; liver; peripheral nervous system ganglion; retina nuclear layer; and testis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 107. Orthologous to human NAPB (NSF attachment protein beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Napb |
| Official Name | N-ethylmaleimide sensitive fusion protein attachment protein beta [Source:MGI Symbol;Acc:MGI:104562] |
| Ensembl ID | ENSMUSG00000027438 |
| Bio databases IDs | |
| Aliases | N-ethylmaleimide sensitive fusion protein attachment protein beta |
| Synonyms | Brp14, b-SNAP, DEE107, E161, I47, N-ethylmaleimide sensitive fusion protein attachment protein beta, N-ethylmaleimide sensitive fusion protein attachment protein β, NSF attachment protein beta, NSF attachment protein β, SNAPB, SNAP-BETA, SNAP-β, SNARE, β-snap |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Napb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
- protein binding
- transporter
- syntaxin binding
- Soluble NSF attachment protein, SNAP
Pathways
Biological processes and signaling networks where the Napb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- intracellular membranes
- Plasma Membrane
- presynaptic membrane
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Napb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic vesicle priming
- SNARE complex disassembly
- intracellular protein transport
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- synaptobrevin 2-SNAP-25-syntaxin-1a complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- soluble NSF attachment protein activity