Rcor1 Gene Summary [Mouse]
Enables chromatin binding activity; enzyme binding activity; and transcription corepressor activity. Involved in erythrocyte differentiation; negative regulation of gene expression; and positive regulation of megakaryocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be part of DNA repair complex; histone deacetylase complex; and transcription repressor complex. Is expressed in several structures, including brain; early embryo; extraembryonic component; liver; and nose. Orthologous to human RCOR1 (REST corepressor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rcor1 |
| Official Name | REST corepressor 1 [Source:MGI Symbol;Acc:MGI:106340] |
| Ensembl ID | ENSMUSG00000037896 |
| Bio databases IDs | |
| Aliases | REST corepressor 1 |
| Synonyms | 5730409O11, 6720480E22Rik, COREST, D12WSU95E, mKIAA0071, RCOR, REST corepressor 1, RGD1305743, Rocr1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rcor1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- ELM2 domain
- Myb-like DNA-binding domain
- transcription co-repressor
- enzyme binding
- chromatin binding
- protein binding
Pathways
Biological processes and signaling networks where the Rcor1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- hepatocellular carcinoma
- epithelial cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- cervical squamous cell carcinoma and endocervical adenocarcinoma
- epithelial uterine cancer
- cervical cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- expression in
- proliferation
- differentiation
- apoptosis
- recruitment in
- number
- silencing in
- silencing
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rcor1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- erythrocyte differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of megakaryocyte differentiation
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- transcriptional repressor complex
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- chromatin binding
- enzyme binding