Dok5 Gene Summary [Mouse]

Acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway; neuron differentiation; and positive regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and immune system. Orthologous to human DOK5 (docking protein 5). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Dok5
Official Name
docking protein 5 [Source:MGI Symbol;Acc:MGI:1924079]
Ensembl ID
ENSMUSG00000027560
Bio databases IDs NCBI: 76829 Ensembl: ENSMUSG00000027560
Aliases docking protein 5
Synonyms 2700055C10Rik, C20orf180, docking protein 5, IRS-6, LOC690989, RGD1562846
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dok5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • PTB domain (IRS-1 type)
  • protein binding
  • phosphotyrosine binding domain
  • Pleckstrin homology-like domain

Pathways

Biological processes and signaling networks where the Dok5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • vascular disease
  • acute myeloid leukemia
  • idiopathic scoliosis
regulated by
regulates
role in cell
  • differentiation
  • outgrowth

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dok5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of nerve growth factor receptor signaling pathway
  • neuron differentiation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • Ras protein signal transduction
  • positive regulation of MAPK cascade

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • cytosol

Gene-Specific Assays for Results You Can Trust

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