Plekha7 Gene Summary [Mouse]
Predicted to enable delta-catenin binding activity. Involved in cell-cell adhesion mediated by cadherin and pore complex assembly. Located in cell-cell junction. Part of pore complex. Is expressed in several structures, including brain ventricular layer; foregut; heart; nasal cavity epithelium; and tooth. Orthologous to human PLEKHA7 (pleckstrin homology domain containing A7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekha7 |
| Official Name | pleckstrin homology domain containing, family A member 7 [Source:MGI Symbol;Acc:MGI:2445094] |
| Ensembl ID | ENSMUSG00000045659 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family A member 7 |
| Synonyms | A430081P20RIK, AI414265, LOC100047292, LOC100289201, LOC100289918, LOC100292788, LOC283278, pleckstrin homology domain containing A7, pleckstrin homology domain containing, family A member 7, RGD1304650 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekha7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prefoldin subunit
- Domain with 2 conserved Trp (W) residues
- afadin binding domain
- prefoldin
- WW
- PH domain
- protein binding
- Pleckstrin homology-like domain
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- pneumonia
- glaucoma
- open-angle glaucoma
- schizophrenia
- coronary artery disease
- insomnia
- cleft lip
- microalbuminuria
role in cell
- expression in
- cell death
- migration
- invasion by
- formation
- formation in
- accumulation in
- assembly
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- centrosome
- intercellular junctions
- cell-cell contacts
- cytosol
- nucleoplasm
- zonula adherens
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekha7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell-cell adhesion
- cell-cell adhesion mediated by cadherin
- pore complex assembly
- zonula adherens maintenance
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- zonula adherens
- pore complex
- cytosol
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- delta-catenin binding
- protein binding