Trpc4 Gene Summary [Mouse]
Enables inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Acts upstream of or within gamma-aminobutyric acid secretion and oligodendrocyte differentiation. Located in caveola. Part of protein-containing complex. Is expressed in several structures, including brain; cochlea; ganglia; genitourinary system; and liver. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Trpc4 |
| Official Name | transient receptor potential cation channel, subfamily C, member 4 [Source:MGI Symbol;Acc:MGI:109525] |
| Ensembl ID | ENSMUSG00000027748 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily C, member 4 |
| Synonyms | CCE1, HTRP-4, STRPC4, transient receptor potential cation channel subfamily C member 4, transient receptor potential cation channel, subfamily C, member 4, TRP4, Trrp4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- calcium channel
- beta-catenin binding
- Ankyrin repeats (3 copies)
- store-operated calcium channel
- protein binding
- ion channel
- phosphorylation site
- inositol 1,4,5-triphosphate receptor binding domain
- binding protein
- Transient receptor ion channel II
- cadherin binding
- transient-receptor-potential calcium channel protein
- CIRB domain
- PDZ binding motif
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- Polycystin cation channel
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Trpc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- hyperalgesia
- severe preeclampsia
- myopia
- Tourette syndrome
- myocardial infarction
- hypothermia
- insulin-induced hypoglycemia
role in cell
- activation in
- response
- formation
- proliferation
- phosphorylation in
- differentiation
- tubulation
- density
- retraction
- calcium oscillation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- cortical cytoskeleton
- cell surface
- cell periphery
- cellular membrane
- intercellular junctions
- cell-cell contacts
- microsome
- caveolae
- basolateral membrane
- synaptosomes
- sarcolemma
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion import
- oligodendrocyte differentiation
- calcium ion transport
- cytosolic calcium ion homeostasis
- gamma-aminobutyric acid secretion
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- caveola
- calcium channel complex
- cell-cell junction
- cation channel complex
- basolateral plasma membrane
- plasma membrane
- cortical cytoskeleton
- cell surface
Molecular Function
What the gene product does at the molecular level
- store-operated calcium channel activity
- protein binding
- calcium channel activity
- cadherin binding
- beta-catenin binding
- inositol 1,4,5 trisphosphate binding