Arr3 Gene Summary [Mouse]
Enables opsin binding activity and phosphoprotein binding activity. Acts upstream of or within endocytosis and regulation of protein phosphorylation. Located in photoreceptor outer segment and synapse. Is expressed in retina. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ARR3 (arrestin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arr3 |
| Official Name | arrestin 3, retinal [Source:MGI Symbol;Acc:MGI:2159617] |
| Ensembl ID | ENSMUSG00000060890 |
| Bio databases IDs | |
| Aliases | arrestin 3, retinal |
| Synonyms | Arr4, arrestin 3, arrestin 3, retinal, ARRX, Car, Carfl, Carr, C-ARRESTIN, MYP26, Visual arrestin, X-arrestin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arrestin (or S-antigen), C-terminal domain
- receptor binding domain
- clathrin binding domain
- coated pit binding domain
- phosphoprotein binding
- protein domain specific binding
- protein binding
- Arrestin (or S-antigen), N-terminal domain
- Ap-2 binding domain
Pathways
Biological processes and signaling networks where the Arr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- female-limited X-linked myopia 26
- spinocerebellar ataxia type 7
role in cell
- apoptosis
- activation in
- quantity
- cell rounding
- internalization by
- response in
- clustering
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nerve ending
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- perikaryon
- cone outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein phosphorylation
- signal transduction
- G-protein coupled receptor internalization
- visual perception
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- synapse
- photoreceptor inner segment
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- phosphoprotein binding
- opsin binding