Tdo2

Predicted to enable several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Predicted to be involved in L-tryptophan catabolic process to acetyl-CoA; L-tryptophan catabolic process to kynurenine; and protein homotetramerization. Is expressed in cerebellum; liver; male reproductive gland or organ; and small intestine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tdo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tdo2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tdo2 gene, providing context for its role in the cell.