Tdo2 Gene Summary [Rat]
Enables several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in several processes, including L-tryptophan catabolic process to acetyl-CoA; response to cortisol; and response to nitroglycerin. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tdo2 |
| Official Name | tryptophan 2,3-dioxygenase [Source:RGD Symbol;Acc:68370] |
| Ensembl ID | ENSRNOG00000011612 |
| Bio databases IDs | |
| Aliases | tryptophan 2,3-dioxygenase |
| Synonyms | chky, HYPTRP, TDO, TO, tog, TPH2, TRPO, TRYPTOPHAN 2,3-DIOXYGENASE, Tryptophan Oxygenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tdo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxygen binding
- tryptophan 2,3-dioxygenase
- enzyme
- protein binding
- heme binding
- identical protein binding
- amino acid binding
Pathways
Biological processes and signaling networks where the Tdo2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- epithelial cancer
- liver cancer
- esophageal adenocarcinoma
- idiopathic pulmonary fibrosis
- familial hypertryptophanemia
- diabetic nephropathy
- hepatitis B virus-related hepatocellular carcinoma
- organismal death
role in cell
- expression in
- proliferation
- differentiation
- anoikis
- invasive capability
- migration
- colony formation by
- invasion by
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tdo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- tryptophan catabolic process to kynurenine
- tryptophan catabolic process to acetyl-CoA
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- identical protein binding
- tryptophan 2,3-dioxygenase activity
- protein binding
- metal ion binding
- amino acid binding
- heme binding