Alpk1 Gene Summary [Mouse]
Predicted to enable monosaccharide binding activity and protein serine/threonine kinase activity. Involved in cytoplasmic pattern recognition receptor signaling pathway and innate immune response. Acts upstream of or within response to bacterium. Located in photoreceptor connecting cilium. Orthologous to human ALPK1 (alpha kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alpk1 |
| Official Name | alpha-kinase 1 [Source:MGI Symbol;Acc:MGI:1918731] |
| Ensembl ID | ENSMUSG00000028028 |
| Bio databases IDs | |
| Aliases | alpha-kinase 1 |
| Synonyms | 8430410J10Rik, alpha-kinase 1, LAK, RGD1304613, ROSAH, α-kinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alpk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Alpha kinase family
- protein serine/threonine kinase
- monosaccharide binding
- Alpha-kinase family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- atrial fibrillation
- insomnia
- hereditary disorder
- leukopenia
- rheumatoid arthritis
- corneal ulcer
- retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome
regulates
- IL1B
- CXCL8
role in cell
- expression in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- basal bodies
- centrosome
- cytosol
- connecting cilia
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alpk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic pattern recognition receptor signaling pathway
- cilium morphogenesis
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- centrosome
- spindle pole
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- monosaccharide binding
- protein serine/threonine kinase activity