Rnaseh2a Gene Summary [Mouse]
Predicted to enable RNA-DNA hybrid ribonuclease activity. Acts upstream of or within mismatch repair. Part of ribonuclease H2 complex. Is expressed in several structures, including embryo ectoderm; gut; hemolymphoid system gland; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnaseh2a |
| Official Name | ribonuclease H2, large subunit [Source:MGI Symbol;Acc:MGI:1916974] |
| Ensembl ID | ENSMUSG00000052926 |
| Bio databases IDs | |
| Aliases | ribonuclease H2, large subunit |
| Synonyms | 2400006P09Rik, AGS4, JUNB, RIBONUCLEASE H1 LARGE subunit, ribonuclease H2, large subunit, ribonuclease H2 subunit A, ribonuclease H2, subunit A, RNASEHI, RNHIA, RNHL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnaseh2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNAse H
- ribonuclease H
- ribonuclease
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Aicardi-Goutieres syndrome 4
- Aicardi-Goutieres syndrome
- global developmental delay
- plexiform neurofibroma
- colon epithelial cancer
- Hashimotos encephalitis
- hereditary disorder
- RNASEH2A-related type 1 interferonopathy
- transverse myelitis
role in cell
- migration
- expression in
- proliferation
- cell death
- colony survival
- colony formation
- invasion by
- transcription in
- cohesion
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnaseh2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- mismatch repair
- DNA replication, removal of RNA primer
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- ribonuclease H2 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease H activity
- RNA binding
- metal ion binding
- ribonuclease activity