Kpna1 Gene Summary [Mouse]
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including NLS-bearing protein import into nucleus; satellite cell activation involved in skeletal muscle regeneration; and skeletal muscle satellite cell proliferation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; gut; integumental system; and sensory organ. Orthologous to human KPNA1 (karyopherin subunit alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Kpna1 |
| Official Name | karyopherin (importin) alpha 1 [Source:MGI Symbol;Acc:MGI:103560] |
| Ensembl ID | ENSMUSG00000022905 |
| Bio databases IDs | |
| Aliases | karyopherin (importin) alpha 1 |
| Synonyms | Importin alpha1, IMPORTIN alpha 5, IMPORTIN α 5, IPOA5, KARYOPHERIN alpha 1, karyopherin subunit alpha 1, karyopherin subunit α 1, KARYOPHERIN α 1, mSRP1, NPI-1, RAG cohort protein 2, RCH2, serine-rich RNA polymerase suppressor protein 1, SRP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kpna1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Atypical Arm repeat
- HEAT-like repeat
- importin beta binding domain
- Armadillo/beta-catenin-like repeats
- protein binding
- HEAT repeats
- nuclear localization sequence binding
- armadillo repeat domain
- transporter
Pathways
Biological processes and signaling networks where the Kpna1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- dystocia
- thrombocytopenia
- Parkinson disease
role in cell
- apoptosis
- binding
- expression in
- activation in
- quantity
- transcription in
- proliferation by
- nuclear import in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- cytosol
- nuclear pores
- nucleoplasm
- nuclear envelope
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kpna1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
- regulation of canonical Wnt receptor signaling pathway
- NLS-bearing substrate import into nucleus
- satellite cell activation involved in skeletal muscle regeneration
- regulation of DNA recombination
- regulation of apoptotic process
- satellite cell proliferation
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- postsynaptic density
- cytoplasm
- cytosol
- NLS-dependent protein nuclear import complex
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- nuclear localization sequence binding