Fmnl3 Gene Summary [Mouse]
Enables GTPase activating protein binding activity. Predicted to be involved in several processes, including cortical actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and retina. Orthologous to human FMNL3 (formin like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmnl3 |
| Official Name | formin-like 3 [Source:MGI Symbol;Acc:MGI:109569] |
| Ensembl ID | ENSMUSG00000023008 |
| Bio databases IDs | |
| Aliases | formin-like 3 |
| Synonyms | 2700073B04Rik, FBP11, FHOD3, formin-like 3, FRL2, mKIAA2014, WBP-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmnl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- GTPase binding domain
- formin homology domain 1
- Diaphanous FH3 Domain
- diaphanous autoregulatory domain
- protein binding
- formin homology domain 3
- Diaphanous GTPase-binding Domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmnl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cortical actin cytoskeleton organization
- cytoskeleton organization
- angiogenesis
- cell migration
- actin cytoskeleton organization
- filopodium assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- small GTPase binding
- GTPase activating protein binding