Smyd2 Gene Summary [Mouse]
Enables RNA polymerase II complex binding activity and histone H3K36 methyltransferase activity. Involved in negative regulation of cell population proliferation and peptidyl-lysine dimethylation. Located in cytosol and nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; nasal cavity epithelium; and nervous system. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smyd2 |
| Official Name | SET and MYND domain containing 2 [Source:MGI Symbol;Acc:MGI:1915889] |
| Ensembl ID | ENSMUSG00000026603 |
| Bio databases IDs | |
| Aliases | SET and MYND domain containing 2 |
| Synonyms | 1110020E07Rik, 4930402C15, HSKM-B, KMT3C, SET and MYND domain containing 2, Smyd2 TSS3426, Smyd2 TSS3427, ZMYND14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smyd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysine N-methyltransferase
- protein-lysine N-methyltransferase
- histone methyltransferase
- MYND finger
- histone lysine N-methyltransferase activity (H3-K36 specific)
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- enzyme binding
- enzyme
- p53 binding
- protein binding
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial neoplasia
- epithelial cancer
- cancer
- digestive system cancer
- abdominal cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- expression in
- invasion by
- phosphorylation in
- proliferation
- migration
- apoptosis
- growth
- differentiation
- activation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smyd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of DNA damage response, signal transduction by p53 class mediator
- heart development
- chromatin remodeling
- negative regulation of cell proliferation
- peptidyl-lysine monomethylation
- peptidyl-lysine dimethylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- metal ion binding
- histone methyltransferase activity (H3-K36 specific)
- lysine N-methyltransferase activity
- protein-lysine N-methyltransferase activity
- RNA polymerase II core binding