Depdc1a Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human DEPDC1 (DEP domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Depdc1a |
| Official Name | DEP domain containing 1a [Source:MGI Symbol;Acc:MGI:1923381] |
| Ensembl ID | ENSMUSG00000028175 |
| Bio databases IDs | |
| Aliases | DEP domain containing 1a |
| Synonyms | 5830484J08Rik, DEP.8, DEPDC1A, DEPDC1-V2, DEP domain containing 1, DEP domain containing 1a, SDP35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Depdc1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- transcription regulator
- protein binding
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- neoplasia
- metastasis
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
- organismal death
- HER2 negative hormone receptor negative breast cancer
- non-small cell lung cancer
- non-small cell lung carcinoma
- small cell lung cancer
role in cell
- proliferation
- expression in
- migration
- apoptosis
- growth
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Depdc1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity