Ube2j1 Gene Summary [Mouse]
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Acts upstream of or within ERAD pathway; regulation of cytokine production; and spermatid development. Predicted to be active in endoplasmic reticulum membrane and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Orthologous to human UBE2J1 (ubiquitin conjugating enzyme E2 J1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2j1 |
| Official Name | ubiquitin-conjugating enzyme E2J 1 [Source:MGI Symbol;Acc:MGI:1926245] |
| Ensembl ID | ENSMUSG00000028277 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2J 1 |
| Synonyms | 0710008M05Rik, 1110030I22RIK, CGI-76, HSPC153, HSPC205, HSU93243, Ncube, NCUBE-1, UBC6, UBC6E, Ubc6p, ubiquitin-conjugating enzyme E2, J1, ubiquitin-conjugating enzyme E2J 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2j1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2j1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- teratozoospermia
- osteoarthropathy
- metastasis
- organismal death
- colorectal cancer
- septic shock
- asthenozoospermia
- failure to thrive
role in cell
- proliferation
- cell viability
- degradation in
- growth
- accumulation in
- development
- enzalutamide resistance
- lack
- abnormal quantity
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2j1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- protein polyubiquitination
- regulation of macrophage cytokine production
- regulation of tumor necrosis factor production
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- ubiquitin protein ligase binding