Rragd Gene Summary [Mouse]
Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and positive regulation of TORC1 signaling. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Human ortholog(s) of this gene implicated in renal hypomagnesemia 7, with or without dilated cardiomyopathy. Orthologous to human RRAGD (Ras related GTP binding D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rragd |
| Official Name | Ras-related GTP binding D [Source:MGI Symbol;Acc:MGI:1098604] |
| Ensembl ID | ENSMUSG00000028278 |
| Bio databases IDs | |
| Aliases | Ras-related GTP binding D |
| Synonyms | 5730543C08Rik, bA11D8.2.1, C030003H22RIK, D4Ertd174e, DKFZp761H171, HOMG7, RAGD, Ras-related GTP binding D, Rragd predicted |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rragd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- Gtr1/RagA G protein conserved region
- small GTP-binding protein domain
- GDP binding
- GTPase
- enzyme binding
- coiled-coil domain
- leucine zipper domain
- enzyme
- protein binding
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- systemic autoimmune syndrome
- renal hypomagnesemia type 7 with dilated cardiomyopathy
- renal hypomagnesemia type 7 without dilated cardiomyopathy
- severe acute respiratory syndrome
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- renal hypomagnesemia type 7 with or without dilated cardiomyopathy
- kidney stones
regulates
role in cell
- phosphorylation in
- mitophagy in
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- centrosome
- lysosome
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rragd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid stimulus
- cellular response to leucine
- negative regulation of autophagy
- protein localization
- cellular response to starvation
- positive regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- lysosomal membrane
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- protein heterodimerization activity
- GTPase binding
- GTPase activity
- GDP binding
- binding, bridging