Fmn2 Gene Summary [Mouse]
Predicted to enable actin binding activity. Involved in several processes, including cytoskeleton organization; meiotic nuclear division; and oogenesis. Acts upstream of or within actin filament bundle assembly and meiotic chromosome movement towards spindle pole. Located in several cellular components, including endoplasmic reticulum membrane; microvillus; and spindle. Is expressed in several structures, including brain; ganglia; neural ectoderm; otocyst; and testis. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 47. Orthologous to human FMN2 (formin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmn2 |
| Official Name | formin 2 [Source:MGI Symbol;Acc:MGI:1859252] |
| Ensembl ID | ENSMUSG00000028354 |
| Bio databases IDs | |
| Aliases | formin 2 |
| Synonyms | AABR07021812.1, AU024104, formin 2, LOC100360457, LOC149414 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fmn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- actin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- Alzheimer disease
- coronary artery disease
- diabetic nephropathy
- schizophrenia
- epithelial cancer
- acute myeloid leukemia
- nasopharyngeal carcinoma
- nasopharyngeal cancer
- Dupuytren contracture
role in cell
- growth
- apoptosis
- migration
- invasion by
- assembly
- formation
- organization
- abnormal morphology
- DNA damage response
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- spindle apparatus
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- nucleoli
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fmn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- polar body extrusion after meiotic divisions
- formin-nucleated actin cable assembly
- intracellular transport
- protein transport
- negative regulation of protein catabolic process
- response to DNA damage stimulus
- vesicle-mediated transport
- oogenesis
- negative regulation of apoptotic process
- establishment of meiotic spindle localization
- homologous chromosome movement towards spindle pole involved in homologous chromosome segregation
- cellular response to hypoxia
- positive regulation of double-strand break repair
- cell migration
- actin cytoskeleton organization
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- nucleolus
- plasma membrane
- endoplasmic reticulum membrane
- nucleus
- cytoplasmic vesicle membrane
- perinuclear region of cytoplasm
- microvillus
- cytoplasm
- cell cortex
- spindle
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin binding