Hook1 Gene Summary [Mouse]
Enables actin binding activity and microtubule binding activity. Acts upstream of or within Golgi organization; cytoplasmic microtubule organization; and manchette assembly. Located in microtubule cytoskeleton. Is expressed in embryo; forelimb bud; spermatid; and testis. Orthologous to human HOOK1 (hook microtubule tethering protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hook1 |
| Official Name | hook microtubule tethering protein 1 [Source:MGI Symbol;Acc:MGI:1925213] |
| Ensembl ID | ENSMUSG00000028572 |
| Bio databases IDs | |
| Aliases | hook microtubule tethering protein 1 |
| Synonyms | A930033L17Rik, azh, h-hook1, HK1, hook microtubule-tethering protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hook1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Hook domain-containing proteins superfamily
- microtubule binding
- microtubule binding domain
- Ciliary protein causing Leber congenital amaurosis disease
- HOOK domain
- actin binding
- protein homodimerization
- coiled-coil domain
- protein binding
- identical protein binding
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- BCR-ABL negative atypical chronic myeloid leukemia
role in cell
- assembly
- epithelial-mesenchymal transition
- transport
- development
- organization
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- microtubule cytoskeleton
- tubular endosomal network
- endosomes
- cytosol
- endosome surfaces
- nodes of Ranvier
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hook1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- cytoskeleton-dependent intracellular transport
- endosome organization
- Golgi organization
- protein transport
- early endosome to late endosome transport
- endosome to lysosome transport
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- FHF complex
- cytoplasm
- HOPS complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- actin binding
- dynein light intermediate chain binding
- microtubule binding