Scp2 Gene Summary [Mouse]
Predicted to enable several functions, including C-acyltransferase activity; anion binding activity; and lipid transfer activity. Involved in fatty acid derivative biosynthetic process; fatty acid metabolic process; and regulation of phospholipid biosynthetic process. Located in endoplasmic reticulum; mitochondrion; and peroxisome. Is expressed in several structures, including central nervous system; hair follicle; intestine; liver; and retina layer. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scp2 |
| Official Name | sterol carrier protein 2, liver [Source:MGI Symbol;Acc:MGI:98254] |
| Ensembl ID | ENSMUSG00000028603 |
| Bio databases IDs | |
| Aliases | sterol carrier protein 2, liver |
| Synonyms | C76618, mThiol, NLTP, NSLIPTR, NSL-TP, SCOX, Scp, SCP-CHI, SCP-X, sterol carrier protein 2, sterol carrier protein 2, liver |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- acetyl-CoA acetyltransferases
- cholesterol binding
- phospholipid transporter
- fatty acid binding
- SCP-2 sterol transfer family
- propanoyl-CoA C-acyltransferase
- propionyl-CoA C2-trimethyltridecanoyltransferase
- phosphatidylinositol transporter
- acetyl-CoA C-myristoyltransferase
- protein binding
- receptor binding
- identical protein binding
- lipid transporter
- cond_enzymes
- acetyl-CoA C-acyltransferase
- binding protein
- phosphatidylcholine transporter
- acyl-CoA binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- peripheral arterial disease
- SCPx deficiency
- osteoarthritis
- hypolipidemia
- weight loss
- Alzheimer disease
- progressive familial intrahepatic cholestasis type 1
- atherosclerosis
- edema
role in cell
- apoptosis
- proliferation
- number
- abnormal morphology
- fluidity
- hydrolysis in
- cell death
- structure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- membrane fraction
- mitochondrial fraction
- peroxisomal matrix
- cholesterol-rich microdomain
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- peroxisome membrane
- nucleoplasm
- peroxisomes
- membrane rafts
- peroxisome-enriched fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- fatty acid beta-oxidation using acyl-CoA oxidase
- positive regulation of intracellular cholesterol transport
- alpha-linolenic acid metabolic process
- phospholipid transport
- intracellular cholesterol transport
- bile acid biosynthetic process
- bile acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- membrane
- mitochondrion
- cytosol
- endoplasmic reticulum
- macromolecular complex
- peroxisomal matrix
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- propanoyl-CoA C-acyltransferase activity
- protein binding
- acetyl-CoA C-acyltransferase activity
- cholesterol binding
- long-chain fatty acyl-CoA binding
- fatty-acyl-CoA binding
- oleic acid binding
- receptor binding
- propionyl-CoA C2-trimethyltridecanoyltransferase activity
- acetyl-CoA C-myristoyltransferase activity