Mst1 Gene Summary [Mouse]
Predicted to enable histone kinase activity and receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including embryo implantation; mammary duct terminal end bud growth; and positive regulation of mammary gland epithelial cell proliferation. Located in vacuole. Is expressed in foregut epithelium; liver; and uterus. Orthologous to several human genes including MST1 (macrophage stimulating 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mst1 |
| Official Name | macrophage stimulating 1 (hepatocyte growth factor-like) [Source:MGI Symbol;Acc:MGI:96080] |
| Ensembl ID | ENSMUSG00000032591 |
| Bio databases IDs | |
| Aliases | macrophage stimulating 1 (hepatocyte growth factor-like) |
| Synonyms | D3F15S2, D3F15S2h, D9H3F15S2, DNF15S2, DNF15S2h, E2F2, HGFL, macrophage stimulating 1, macrophage stimulating 1 (hepatocyte growth factor-like), Macrophage stimulatory, MSP, NF15S2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mst1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAN_APPLE
- KR
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- Akt phosphorylation site
- receptor tyrosine kinase binding
- enzyme binding
- PAN domain
- enzyme
- protein binding
- growth factor
Pathways
Biological processes and signaling networks where the Mst1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- colitis
- inflammatory bowel disease
role in cell
- expression in
- cell death
- apoptosis
- activation in
- proliferation
- growth
- survival
- production in
- formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- vacuole
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mst1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- negative regulation of gluconeogenesis
- regulation of JAK-STAT cascade
- regulation of cAMP-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- receptor tyrosine kinase binding