Cyth3 Gene Summary [Mouse]
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within establishment of epithelial cell polarity and positive regulation of cell adhesion. Located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Is expressed in brain. Orthologous to human CYTH3 (cytohesin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyth3 |
| Official Name | cytohesin 3 [Source:MGI Symbol;Acc:MGI:1335107] |
| Ensembl ID | ENSMUSG00000018001 |
| Bio databases IDs | |
| Aliases | cytohesin 3 |
| Synonyms | ARNO3, CLM3, CYTOHESIN 3, GRP1, PSCD3, Sec7, Sec7C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyth3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3,4,5-triphosphate binding
- Sec7
- Sec7 domain
- guanyl-nucleotide exchange factor
- PH domain
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- Shigella infection
- sleep-wake schedule disorder
role in cell
- fragmentation
- adhesion
- transport
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Plasma Membrane
- cytosol
- Golgi membrane
- nucleoplasm
- tight junctions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyth3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
- establishment of epithelial cell polarity
- positive regulation of cell adhesion
- Golgi vesicle transport
Cellular Component
Where in the cell the gene product is active
- adherens junction
- tight junction
- ruffle
- cytosol
- Golgi membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- guanyl-nucleotide exchange factor activity