Plxna1 Gene Summary [Mouse]
Enables semaphorin receptor activity. Involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; nervous system development; and semaphorin-plexin signaling pathway. Acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in membrane. Part of semaphorin receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plxna1 |
| Official Name | plexin A1 [Source:MGI Symbol;Acc:MGI:107685] |
| Ensembl ID | ENSMUSG00000030084 |
| Bio databases IDs | |
| Aliases | plexin A1 |
| Synonyms | 2600013D04RIK, DKFZP564A176, DWOPNED, mKIAA4053, NOV, NOVP, PlexA1, PLEXIN 1, PLEXIN-A1, PLXN1, RGD1560871 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxna1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- ectodomain
- protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- cytoplasmic domain
- transmembrane domain
- TIG domain found in plexin
- IPT/TIG domain
- intracellular domain
- semaphorin receptor
- plexin/semaphorin/integrin domain
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Plxna1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Dworschak-Punetha neurodevelopmental syndrome
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- neurodevelopmental disorder
- alcoholic pancreatitis
- lepromatous leprosy
role in cell
- phosphorylation in
- morphology
- migration
- collapse
- rearrangement
- contraction
- rearrangement in
- function
- outgrowth
- outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- cytosol
- nucleoplasm
- growth cone
- neurites
- synapse
- cytoplasmic vesicles
- perikaryon
- axons
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxna1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- positive regulation of axonogenesis
- negative regulation of cell adhesion
- olfactory nerve formation
- regulation of GTPase activity
- regulation of smooth muscle cell migration
- regulation of cell migration
- dichotomous subdivision of terminal units involved in salivary gland branching
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- extracellular vesicular exosome
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- semaphorin receptor activity