ERRFI1
ERRFI1 Gene Summary
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ERRFI1 |
| Official Name | ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185] |
| Ensembl ID | ENSG00000116285 |
| Bio databases IDs | |
| Aliases | ERBB receptor feedback inhibitor 1 |
| Synonyms | 1300002F13RIK,CTA-215D11.2,ERBB receptor feedback inhibitor 1,G33,GENE-33,MIG-6,RALT,RGD1307599,Xxx |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- protein kinase binding
- GTPase binding
- enzyme binding
- GTPase activator
- protein binding
- EGFR receptor inhibitor Mig-6
- Ack homology domain
- SH3-domain binding
Pathways
Biological processes and signaling networks where the ERRFI1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GRB2
- ARRDC5
- NFKBIA
- ERBB2
- EGFR
- STX8
- SRC
- AKT1
- YWHAG
- NR3C1
disease
- neoplasia
- osteoarthritis
- non-insulin-dependent diabetes mellitus
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- cancer
- papillomatosis
- endometrial cancer
regulated by
- NFE2L2
- insulin
- dexamethasone
- INS
- metribolone
- beta-estradiol
- hydrocortisone
- NEDD4
- forskolin
- NDRG1
regulates
- CASP3
- JNK
- H2AX
- IL1B
- TNF
- D-glucose
- AKT
- ERK1/2
- MAPK1
- lipid
role in cell
- apoptosis
- activation in
- growth
- expression in
- quantity
- number
- differentiation
- phosphorylation in
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ERRFI1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of epidermal growth factor-activated receptor activity
- epidermal growth factor receptor signaling pathway
- response to progesterone stimulus
- cholesterol metabolic process
- lung vasculature development
- lung epithelium development
- response to xenobiotic stimulus
- glucose metabolic process
- skin morphogenesis
- negative regulation of epidermal growth factor receptor signaling pathway
- cholesterol homeostasis
- lung alveolus development
- protein kinase B signaling cascade
- epithelial cell proliferation
- response to insulin stimulus
- liver development
- apoptotic process
- cell migration
- negative regulation of protein autophosphorylation
- regulation of keratinocyte differentiation
- limb joint morphogenesis
- fat pad development
- bile acid biosynthetic process
- embryo implantation
- tissue homeostasis
- progesterone receptor signaling pathway
- response to estradiol stimulus
- chondrocyte proliferation
- gene expression
- uterine epithelium development
- protein localization in plasma membrane
- cartilage development
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- GTPase activator activity