Fes Gene Summary [Mouse]
Enables microtubule binding activity and protein kinase activity. Acts upstream of or within centrosome cycle and microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Fes |
| Official Name | feline sarcoma oncogene [Source:MGI Symbol;Acc:MGI:95514] |
| Ensembl ID | ENSMUSG00000053158 |
| Bio databases IDs | |
| Aliases | feline sarcoma oncogene |
| Synonyms | c-fes, feline sarcoma oncogene, FES proto-oncogene, tyrosine kinase, FPS, RGD1564385, V-FPS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fes often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- Fes/CIP4, and EFC/F-BAR homology domain
- non-membrane spanning protein tyrosine kinase
- protein binding
- receptor binding
- protein-tyrosine kinase
- Protein kinase domain
- Bin/Amphiphysin/Rvs domain
- phosphatidylinositol binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- microtubule binding
- kinase domain
- Protein Kinases, catalytic domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Fes gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- advanced non-small cell lung adenocarcinoma
- advanced lung squamous cell carcinoma
- advanced non-small cell lung cancer
- advanced large cell lung carcinoma
- metastatic large cell lung carcinoma
- inflammatory myofibroblastic tumor
- metastatic lung adenocarcinoma
- coronary artery disease
- metastatic non-small cell lung cancer
- myocardial infarction
role in cell
- quantity
- migration
- growth
- activation in
- adhesion
- cell spreading
- number
- phosphorylation in
- differentiation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- perinuclear region
- focal adhesions
- Nucleus
- microtubules
- microtubule organizing centers
- cytosol
- cytoplasmic face of plasma membrane
- growth cone
- neurites
- cytoplasmic vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fes gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- peptidyl-tyrosine phosphorylation
- positive regulation of myeloid cell differentiation
- centrosome cycle
- protein autophosphorylation
- cell adhesion
- regulation of vesicle-mediated transport
- protein phosphorylation
- cardiac muscle cell proliferation
- regulation of cell proliferation
- regulation of mast cell degranulation
- positive regulation of monocyte differentiation
- chemotaxis
- microtubule bundle formation
- regulation of cell differentiation
- myoblast proliferation
- regulation of cell motility
- positive regulation of neuron projection development
- regulation of cell adhesion
- positive regulation of microtubule polymerization
- cellular response to vitamin D
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- focal adhesion
- cytoplasm
- cytosol
- cytoplasmic vesicle
- Golgi apparatus
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- phosphatidylinositol binding
- immunoglobulin receptor binding
- microtubule binding