Spr

Enables protein homodimerization activity and sepiapterin reductase (NADP+) activity. Involved in tetrahydrobiopterin biosynthetic process. Acts upstream of or within several processes, including L-phenylalanine metabolic process; catecholamine metabolic process; and voluntary musculoskeletal movement. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Spr gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Spr gene, providing context for its role in the cell.