Tiam2 Gene Summary [Mouse]
Enables GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of axonogenesis and small GTPase-mediated signal transduction. Located in cytoplasm and membrane. Is expressed in several structures, including cartilage; central nervous system; genitourinary system; liver; and respiratory system. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tiam2 |
| Official Name | T cell lymphoma invasion and metastasis 2 [Source:MGI Symbol;Acc:MGI:1344338] |
| Ensembl ID | ENSMUSG00000023800 |
| Bio databases IDs | |
| Aliases | T cell lymphoma invasion and metastasis 2 |
| Synonyms | 3000002F19RIK, LOC100362710, mKIAA2016, STEF, T cell lymphoma invasion and metastasis 2, TIAM Rac1 associated GEF 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tiam2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- tiam1-stef-sif homologous domain
- canonical PDZ domain
- T-lymphoma invasion and metastasis CC-Ex domain
- GTPase activator
- enzyme
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- RhoGEF domain
- RhoGEF
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- PH domain
- cpPDZ_Deg_HtrA-like
- Dbl homology domain
- HR1
Pathways
Biological processes and signaling networks where the Tiam2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- necrotizing enterocolitis
- respiratory disorder
- androgenic alopecia
- rotator cuff injury
- asthma
- nicotine withdrawal syndrome
- productive infection by HIV-1
role in cell
- apoptosis
- proliferation
- expression in
- growth
- migration
- formation
- number
- length
- ruffling
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- growth cone
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tiam2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of axonogenesis
- small GTPase mediated signal transduction
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- growth cone
- extracellular vesicular exosome
- membrane
- cytosol
- filopodium
- synapse
- perikaryon
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity
- guanyl-nucleotide exchange factor activity