Hsph1 Gene Summary [Mouse]
Enables alpha-tubulin binding activity. Acts upstream of or within chaperone cofactor-dependent protein refolding. Colocalizes with microtubule. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and limb. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsph1 |
| Official Name | heat shock 105kDa/110kDa protein 1 [Source:MGI Symbol;Acc:MGI:105053] |
| Ensembl ID | ENSMUSG00000029657 |
| Bio databases IDs | |
| Aliases | heat shock 105kDa/110kDa protein 1 |
| Synonyms | heat shock 105kDa/110kDa protein 1, Heat shock protein 105 kda, heat shock protein family H (Hsp110) member 1, HS105, HSP105, HSP105A, HSP105B, HSP110, hsp110/105, hsp-E7I, KIAA0201, NY-CO-25 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsph1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenyl-nucleotide exchange factor
- alpha-tubulin binding
- protein binding
- Hsp70 protein
- loop domain
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hsph1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- pulmonary hypertensive arterial disease
- T acute lymphoblastic leukemia
- Alzheimer disease
- activated B-cell-like diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- multiple system atrophy
- schizophrenia
role in cell
- expression in
- activation
- phosphorylation in
- apoptosis
- migration
- cell death
- survival
- proliferation
- function
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- organelle lumens
- Nucleus
- Mitochondria
- microtubules
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsph1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of NK T cell activation
- chaperone mediated protein folding requiring cofactor
- positive regulation of MHC class I biosynthetic process
- protein folding
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- endocytic vesicle lumen
- cytosol
- macromolecular complex
- extracellular region
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- alpha-tubulin binding
- adenyl-nucleotide exchange factor activity