Kel Gene Summary [Mouse]
Enables metallopeptidase activity. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; regulation of axon diameter; and skeletal muscle fiber development. Located in membrane. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kel |
| Official Name | Kell blood group [Source:MGI Symbol;Acc:MGI:1346053] |
| Ensembl ID | ENSMUSG00000029866 |
| Bio databases IDs | |
| Aliases | Kell blood group |
| Synonyms | CD238, ECE3, KELL, Kell blood group, Kell metallo-endopeptidase (Kell blood group), RGD1565470 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kel often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- endopeptidase
- neprilysin
- peptidase
- transmembrane domain
- intracellular domain
- protein binding
- peptidase GluZincin family
- Peptidase family M13
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Kel gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- yolk sac neoplasm
- germ cell neoplasia
- centronuclear myopathy
- shortened PR interval
- atopic dermatitis
- gait disturbance
- infection by HIV-1
role in cell
- quantity
- abnormal morphology
- size
- homeostasis in
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- erythrocyte membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kel gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- skeletal muscle fiber development
- regulation of cell size
- protein processing
- vasoconstriction
- myelination
- establishment of localization in cell
- regulation of axon diameter
- cellular magnesium ion homeostasis
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity