Tenm1 Gene Summary [Mouse]
Enables protein heterodimerization activity and protein homodimerization activity. Involved in positive regulation of cellular component biogenesis; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase III. Located in several cellular components, including extracellular region; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TENM1 (teneurin transmembrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tenm1 |
| Official Name | teneurin transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:1345185] |
| Ensembl ID | ENSMUSG00000016150 |
| Bio databases IDs | |
| Aliases | teneurin transmembrane protein 1 |
| Synonyms | LOC103690896, LOC683585, ODZ1, Odz2, ODZ3, ODZ, ODD OZ/TEN-M HOMOLOG 3, RGD1561678, TCAP-1, TEN1, teneurin transmembrane protein 1, TNM, TNM1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tenm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- RHS repeat-associated core domain
- Keratin, high sulfur B2 protein
- protein binding
- NHL repeat unit of beta-propeller proteins
- identical protein binding
- EGF-like domain
- Family of unknown function (DUF5885)
- EGF_CA
- GHH signature containing HNH/Endo VII superfamily nuclease toxin
- Delta serrate ligand
- YD repeat (two copies)
- intracellular domain
- protein homodimerization
- Teneurin Intracellular Region
- heparin binding
- transmembrane receptor
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- urothelial bladder carcinoma
- liver cancer
- transitional cell bladder cancer
- hepatocellular carcinoma
- gastric adenocarcinoma
- gastric epithelial cancer
- sarcoma
- primary antiphospholipid antibody syndrome
role in cell
- expression in
- proliferation
- assembly
- polymerization
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytoskeleton
- Cytoplasm
- Extracellular Space
- perinuclear region
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- nuclear speckles
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tenm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of intracellular protein transport
- negative regulation of cell proliferation
- nervous system development
- positive regulation of filopodium assembly
- heterophilic cell-cell adhesion
- neuron development
- regulation of transcription from RNA polymerase III promoter
- neuropeptide signaling pathway
- immune response
- positive regulation of actin filament polymerization
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoskeleton
- cytoplasm
- nuclear speck
- nuclear matrix
- Golgi apparatus
- endoplasmic reticulum
- extracellular region
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein heterodimerization activity
- cell adhesion molecule binding
- heparin binding