Tnfaip8l1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Involved in negative regulation of TOR signaling. Located in cytoplasm. Orthologous to human TNFAIP8L1 (TNF alpha induced protein 8 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tnfaip8l1 |
| Official Name | tumor necrosis factor, alpha-induced protein 8-like 1 [Source:MGI Symbol;Acc:MGI:1913693] |
| Ensembl ID | ENSMUSG00000044469 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor, alpha-induced protein 8-like 1 |
| Synonyms | 2600017J23Rik, TIPE1, TNF alpha induced protein 8 like 1, TNF α induced protein 8 like 1, tumor necrosis factor, alpha-induced protein 8-like 1, tumor necrosis factor, α-induced protein 8-like 1, tumour necrosis factor, alpha-induced protein 8-like 1, tumour necrosis factor, α-induced protein 8-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfaip8l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF758)
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- osteosarcoma
- osteosarcomagenesis
- metastasis
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- chronic colitis
- dextran sodium sulfate-induced colitis
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- growth
- activation
- migration
- colony formation
- invasion by
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfaip8l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of apoptotic process
- negative regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding