Rad51ap1 Gene Summary [Mouse]
Predicted to enable DNA binding activity and RNA binding activity. Acts upstream of or within DNA recombination. Located in chromosome and nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; gut; reproductive system; and trachea. Orthologous to human RAD51AP1 (RAD51 associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad51ap1 |
| Official Name | RAD51 associated protein 1 [Source:MGI Symbol;Acc:MGI:1098224] |
| Ensembl ID | ENSMUSG00000030346 |
| Bio databases IDs | |
| Aliases | RAD51 associated protein 1 |
| Synonyms | 2510006L10Rik, LOC683109, PIR51, RAB22, RAD51 associated protein 1, RAD51-INTERACTING |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad51ap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RAD51 interacting motif
- single-stranded DNA binding
- double-stranded DNA binding
- DNA secondary structure binding
- protein binding
- DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- metastasis
- nonsyndromic cleft lip and palate
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- non-small cell lung cancer
- small cell lung cancer
role in cell
- expression in
- proliferation
- apoptosis
- growth
- migration
- quantity
- invasion by
- cell cycle progression
- DNA damage response
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad51ap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- meiotic cell cycle
- positive regulation of reciprocal meiotic recombination
- cellular response to ionizing radiation
- double-strand break repair via homologous recombination
- regulation of double-strand break repair via homologous recombination
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- macromolecular complex
- chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- double-stranded DNA binding
- DNA secondary structure binding
- single-stranded DNA binding