Gipr Gene Summary [Mouse]
Enables gastric inhibitory peptide receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of insulin secretion. Acts upstream of or within endocrine pancreas development. Is active in plasma membrane. Is expressed in cortical plate; foregut-midgut junction; neck; and thyroid gland. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gipr |
| Official Name | gastric inhibitory polypeptide receptor [Source:MGI Symbol;Acc:MGI:1352753] |
| Ensembl ID | ENSMUSG00000030406 |
| Bio databases IDs | |
| Aliases | gastric inhibitory polypeptide receptor |
| Synonyms | gastric inhibitory polypeptide receptor, Gippr, GLUCOSE-DEPENDENT INSULINOTROPIC PEPTIDE receptor, Gm1081, Gm160, PGQTL2, RATGIPPR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gipr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- signaling receptor activity
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- gastric inhibitory peptide receptor
- polypeptide hormone binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Gipr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- insulin resistance
- morbid obesity
- non-insulin-dependent diabetes mellitus
- overweight disorder
- obesity
- carcinoma in situ
- epithelial cancer in situ
- coronary artery disease
- psoriatic arthritis
role in cell
- cell death
- apoptosis
- phosphorylation in
- expression in
- activation in
- lipolysis in
- response
- number
- elevation in
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gipr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- response to axon injury
- response to nutrient
- positive regulation of cAMP-mediated signaling
- cell surface receptor signaling pathway
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- regulation of insulin secretion
- response to glucose stimulus
- desensitization of G-protein coupled receptor protein signaling pathway
- response to calcium ion
- response to fatty acid
- positive regulation of insulin secretion
- endocrine pancreas development
- activation of adenylate cyclase activity
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- transmembrane signaling receptor activity
- protein binding
- gastric inhibitory peptide receptor activity
- peptide hormone binding