Sytl2 Gene Summary [Mouse]
Enables neurexin family protein binding activity. Involved in exocytosis and positive regulation of mucus secretion. Acts upstream of or within protein localization to plasma membrane. Located in melanosome and plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SYTL2 (synaptotagmin like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sytl2 |
| Official Name | synaptotagmin-like 2 [Source:MGI Symbol;Acc:MGI:1933366] |
| Ensembl ID | ENSMUSG00000030616 |
| Bio databases IDs | |
| Aliases | synaptotagmin-like 2 |
| Synonyms | CHR11SYT, EXO4, EXOPHILIN 4, LOC100911824, mKIAA1597, PPP1R151, SGA72M, SLP2, synaptotagmin-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sytl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Rab binding domain
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- neurexin binding
- protein binding
- Slp homology domain
- Protein kinase C conserved region 2 (CalB)
- phosphatase binding
- C2 domain
- Rab27 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic autoimmune syndrome
- organismal death
- metastasis
- androgenic alopecia
- latent tuberculosis
- drug-induced liver disease
- septic shock
role in cell
- quantity
- formation in
- formation
- degradation in
- migration
- morphology
- docking
- abnormal morphology
- invasion by
- anchoring
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- exocytic vesicle
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- immunological synapses
- granules
- cytosol
- apical cell surfaces
- melanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sytl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- vesicle docking involved in exocytosis
- intracellular protein transport
- exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- cytoplasm
- melanosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- protein binding
- neurexin family protein binding
- small GTPase binding