Thap12 Gene Summary [Mouse]
Predicted to enable DNA binding activity; protein dimerization activity; and zinc ion binding activity. Located in nucleus. Is expressed in 1st branchial arch; 2nd branchial arch; heart; and trunk. Orthologous to human THAP12 (THAP domain containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Thap12 |
| Official Name | THAP domain containing 12 [Source:MGI Symbol;Acc:MGI:1920231] |
| Ensembl ID | ENSMUSG00000030753 |
| Bio databases IDs | |
| Aliases | THAP domain containing 12 |
| Synonyms | 2900052B10Rik, DAP4, P52rIPK, P58INK, PRKRIR, Rpkrir, THAP0, THAP domain containing 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thap12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- THAP domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- apoptosis
- proliferation
- growth
- survival
- G1/S phase transition
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thap12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- protein dimerization activity