THAP12 Gene Summary [Human]
Predicted to enable DNA binding activity; metal ion binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of cell population proliferation and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | THAP12 |
| Official Name | THAP domain containing 12 [Source:HGNC Symbol;Acc:HGNC:9440] |
| Ensembl ID | ENSG00000137492 |
| Bio databases IDs | |
| Aliases | THAP domain containing 12, death-associated protein 4, P58IPK-regulatory protein, 52 kDa repressor of the inhibitor of the protein kinase |
| Synonyms | 2900052B10Rik, DAP4, P52rIPK, P58INK, PRKRIR, Rpkrir, THAP0, THAP domain containing 12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THAP12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- THAP domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- apoptosis
- proliferation
- growth
- survival
- G1/S phase transition
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THAP12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- protein dimerization activity