Arhgap17 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction; regulation of Rac protein signal transduction; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in plasma membrane. Is expressed in facial prominence ectoderm; limb; and limb mesenchyme. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap17 |
| Official Name | Rho GTPase activating protein 17 [Source:MGI Symbol;Acc:MGI:1917747] |
| Ensembl ID | ENSMUSG00000030766 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 17 |
| Synonyms | 5730403H17Rik, LOC100129892, MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, Nadrin2, PP367, PP4534, Rho GTPase activating protein 17, RICH-1, RICH-1B, WBP15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- BAR domain
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- diffuse large B-cell lymphoma
- hepatocellular carcinoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- gout
- liver cirrhosis
- septic shock
regulates
role in cell
- growth
- growth in
- organization
- cell cycle progression
- outgrowth
- ruffling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- Plasma Membrane
- vesicles
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin cytoskeleton organization
- signal transduction
- regulation of Rac protein signal transduction
- actin filament organization
- calcium ion-dependent exocytosis
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytosol
- intracellular
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- SH3 domain binding