Wdr4 Gene Summary [Mouse]
Predicted to enable tRNA methyltransferase activator activity. Predicted to be involved in tRNA (guanine-N7)-methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and microcephaly, growth deficiency, seizures, and brain malformations. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr4 |
| Official Name | WD repeat domain 4 [Source:MGI Symbol;Acc:MGI:1889002] |
| Ensembl ID | ENSMUSG00000024037 |
| Bio databases IDs | |
| Aliases | WD repeat domain 4 |
| Synonyms | D530049K22Rik, GAMOS6, hWH, MIGSB, mWH, TRM82, TRMT82, WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit, WD repeat domain 4, Wh, Wuho |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40
- protein binding
- enzyme regulator activity
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- Galloway-Mowat syndrome 6
- hereditary disorder
- cholangiocarcinoma cancer
- acute myeloid leukemia
- organismal death
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- liver cancer
role in cell
- growth
- migration
- invasion by
- apoptosis
- degradation in
- cell death
- proliferation
- G2/M phase
- sorafenib sensitivity
- co-localization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to DNA damage stimulus
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- tRNA methyltransferase complex
- nucleus
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme activator activity