Bcat2 Gene Summary [Mouse]
Enables branched-chain-amino-acid transaminase activity. Acts upstream of or within branched-chain amino acid metabolic process; cellular response to leukemia inhibitory factor; and regulation of hormone levels. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study maple syrup urine disease. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to human BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcat2 |
| Official Name | branched chain aminotransferase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:1276534] |
| Ensembl ID | ENSMUSG00000030826 |
| Bio databases IDs | |
| Aliases | branched chain aminotransferase 2, mitochondrial |
| Synonyms | BCAM, BCATM, Bcat(m), BCT2, Branched-chain alpha-keto acid transporter, branched chain amino acid transaminase 2, branched chain aminotransferase 2, mitochondrial, Branched-chain α-keto acid transporter, Eca40, HVLI, mBcat, PP18 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thyroid-hormone transaminase
- PLPDE_IV
- Amino-transferase class IV
- branched-chain-amino-acid transaminase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Bcat2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- idiopathic scoliosis
- obesity
- polyuria
- hepatocellular carcinoma
- liver cancer
- hypervalinemia and hyperleucine-isoleucinemia
- diabetes mellitus
phenotypes
- abnormal circulating amino acid level
- abnormal circulating hormone level
- abnormal food preference
- abnormal glucose homeostasis
- abnormal homeostasis
- abnormal lipid homeostasis
- abnormal urine amino acid level
- bradykinesia
- decreased body weight
- decreased circulating adiponectin level
- decreased circulating free fatty acid level
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating ketone body level
- decreased circulating leptin level
- decreased epididymal fat pad weight
- decreased percent body fat/body weight
- decreased susceptibility to diet-induced obesity
- decreased urine creatinine level
- enlarged kidney
- improved glucose tolerance
- increased core body temperature
- increased energy expenditure
- increased food intake
- increased insulin sensitivity
- increased lean body mass
- ketoaciduria
- polyuria
- premature death
- preweaning lethality incomplete penetrance
- sparse hair
- thin hair shaft
- weakness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of hormone levels
- valine biosynthetic process
- lipid metabolic process
- leucine biosynthetic process
- isoleucine catabolic process
- branched chain family amino acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- L-leucine transaminase activity
- L-valine transaminase activity
- L-leucine:2-oxoglutarate aminotransferase activity
- branched-chain-amino-acid transaminase activity
- L-isoleucine transaminase activity