Bcat2 Gene Summary [Rat]
Enables L-isoleucine-2-oxoglutarate transaminase activity; L-leucine-2-oxoglutarate transaminase activity; and L-valine-2-oxoglutarate transaminase activity. Involved in L-leucine biosynthetic process; isoleucine catabolic process; and lactation. Is active in mitochondrion. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to human BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcat2 |
| Official Name | branched chain amino acid transaminase 2 [Source:RGD Symbol;Acc:68948] |
| Ensembl ID | ENSRNOG00000020956 |
| Bio databases IDs | |
| Aliases | branched chain amino acid transaminase 2 |
| Synonyms | BCAM, BCATM, Bcat(m), BCT2, Branched-chain alpha-keto acid transporter, branched chain amino acid transaminase 2, branched chain aminotransferase 2, mitochondrial, Branched-chain α-keto acid transporter, Eca40, HVLI, mBcat, PP18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thyroid-hormone transaminase
- PLPDE_IV
- Amino-transferase class IV
- branched-chain-amino-acid transaminase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Bcat2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- idiopathic scoliosis
- obesity
- polyuria
- hepatocellular carcinoma
- liver cancer
- hypervalinemia and hyperleucine-isoleucinemia
- diabetes mellitus
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of hormone levels
- valine biosynthetic process
- lipid metabolic process
- leucine biosynthetic process
- isoleucine catabolic process
- branched chain family amino acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- L-leucine transaminase activity
- L-valine transaminase activity
- L-leucine:2-oxoglutarate aminotransferase activity
- branched-chain-amino-acid transaminase activity
- L-isoleucine transaminase activity