Ern2 Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and unfolded protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JUN kinase activity; and regulation of DNA-templated transcription. Located in endoplasmic reticulum quality control compartment. Part of IRE1-TRAF2-ASK1 complex. Is expressed in central nervous system and retina. Orthologous to human ERN2 (endoplasmic reticulum to nucleus signaling 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ern2 |
| Official Name | endoplasmic reticulum (ER) to nucleus signalling 2 [Source:MGI Symbol;Acc:MGI:1349436] |
| Ensembl ID | ENSMUSG00000030866 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum (ER) to nucleus signalling 2 |
| Synonyms | endoplasmic reticulum to nucleus signaling 2, endoplasmic reticulum to nucleus signalling 2, Ern1, hIRE2p, Ire1, IRE1b, IRE1-BETA, IRE1-β, IRE2p, mIre1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ern2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease domain
- RNase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- PQQ-dependent dehydrogenases and related proteins
- ATP binding
- PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
- beta-propeller repeat
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- endonuclease
- kinase domain
- Protein Kinases, catalytic domain
- lumenal domain
- RNase_Ire1_like
- luminal/IRE1-like
- cytosolic tail domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- colitis
- infection by vesicular stomatitis virus
- productive infection by HIV-1
role in cell
- cell death
- activation in
- accumulation in
- autophagy by
- condensation
- distension in
- endoplasmic reticulum stress response
- distension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ern2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- rRNA catabolic process
- apoptotic chromosome condensation
- mRNA processing
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- protein phosphorylation
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum quality control compartment
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- endonuclease activity
- unfolded protein binding
- protein serine/threonine kinase activity
- endoribonuclease activity